Hemostatic Dressings Made of Oxidized Bacterial Nanocellulose Membranes

Surgicel® (regenerated oxidized cellulose) is a bio-absorbable hemostatic material widely applied to prevent surgery-derived adhesions. Some critical issues have been reported associated with this biomaterial, which we aimed overcome by producing bacterial nanocellulose (BNC) membranes activity, through electrochemical oxidation using the tetramethylpiperidine-1-oxyl (TEMPO) radical. Samples were characterized FTIR, NMR, SEM, XRD and their degree of polymerization. The was evaluated titration carboxyl groups behavior whole-blood-clotting assays. In vitro in vivo biodegradability BNC compared that Surgicel®. increased from 4% 7% up 15%, corresponding an charge 400, 700 1200 Coulombs, respectively. preserved crystallinity 3D nano-fibrillar network, demonstrated although not as effective assays did induce inflammatory response, revealing good biocompatibility. However, non-degraded still detected at implantation site after 56 days.